Forum for Science, Industry and Business

Biodegradable colloidal particles for inhalative administration

Now nanoparticular transport vehicles are available, which absorb active ingredients and release them at the desired location, i.e. the lungs. In particular, these are biodegradable particles, which are composed of a biologically degradable amphiphilic comb polymer, which is based on a polyol backbone with positively charged side chains. The biodegradable particles are suitable for simple and patient-friendly application, in particular for inhalative administration of pharmaceutical agents for the treatment of diseases in humans and higher mammals.<br><br> The particles remain stable during the process of aerosol production, i.e. through nebulisation and release the agents continuously after deposition in the lungs, whereby a constant drug level is ensured. It is of particular advantage that, due to this targeted administration of pharmaceutical agents, the number of necessary inhalations can be considerably reduced.

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