Risk prognosis method for chronic lymphocytic leukemia
The clinical course of chronic lymphocytic leukemia (CLL) is highly variable, ranging from slow progression and survival for several decades to rapidly progressive and chemotherapy-resistant disease with death within one year of diagnosis.
<p> An alternative to FISH based diagnostics has been established. A prognostic score (PS.8) for OS using the largest GEP data set available for CLL patients with long-term follow-up and validation in 149 patients has been developed. A simple but powerful gene expression score predicting overall survival (OS) and time-to-treatment (TTT) in CLL patients has been established and can easily be assayed in a routine diagnostics setting. The novel test is fast and cost effective with excellent predictive power. It is based on the expression levels of just eight selected genes that could be measured easily by qRT-PCR. <p> Next development steps include prospective confirmatory trials to assess the relevance of PS.8 to guide individualized treatment choices to improve the clinical outcome of CLL patients: <p> • Validation in prospective trials (i.e. performance of overall survival prediction for rituximab therapy) <p> • Possible role in prediction of treatment response – identification of pathway specific treatment response <p> • Characterization of the molecular/biological function of genes involved in the score
Further Information: PDF
Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0
Contact
Peer Biskup
Media Contact
All latest news from the category: Technology Offerings
Newest articles
High-energy-density aqueous battery based on halogen multi-electron transfer
Traditional non-aqueous lithium-ion batteries have a high energy density, but their safety is compromised due to the flammable organic electrolytes they utilize. Aqueous batteries use water as the solvent for…
First-ever combined heart pump and pig kidney transplant
…gives new hope to patient with terminal illness. Surgeons at NYU Langone Health performed the first-ever combined mechanical heart pump and gene-edited pig kidney transplant surgery in a 54-year-old woman…
Biophysics: Testing how well biomarkers work
LMU researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy. Modern microscopy techniques make it possible to examine the inner workings…