Clot Lysis Assay ? measurement of fibrinolysis in all parts of the reaction
At present, the fibrinolysis system is measured chromogenically via the enzyme activity of plasmin as a matter of routine. As the last reaction of fibrinolysis, i.e. the dissolution of fibrin strains, cannot be detected, this measurement system is only in part physiologi-cal.
The invention on hand provides a novel method rendering it possible to measure all steps of the fibrinolysis reaction, especially the dissolution of fibrin strain. Conventional microtiter plates containing micro thrombi are used in this novel clot lysis assay. Lysis is determined based on the regressing turbidity of the thrombus. Thereby, several different thrombolytic agents can be compared with each other. Both exogenic stimulation of plasmatic thrombolysis and intrinsic plasmatic thrombolysis of plasminogen activators can be measured. Experiments hitherto carried out with the novel clot lysis assay clearly indicate that different thrombolytic agents lead zu different clinical results, which most likely depend on endogenous thrombi.
Further Information: PDF
TransMIT Gesellschaft für Technologietransfer mbH
Phone: +49 (0)641/943 64-12
Dr. Peter Stumpf
All news from this category: Technology Offerings
Bringing atoms to a standstill: NIST miniaturizes laser cooling
It’s cool to be small. Scientists at the National Institute of Standards and Technology (NIST) have miniaturized the optical components required to cool atoms down to a few thousandths of…
Record-breaking laser link could help us test whether Einstein was right
Scientists from the International Centre for Radio Astronomy Research (ICRAR) and The University of Western Australia (UWA) have set a world record for the most stable transmission of a laser signal through…
Adaptive optics with cascading corrective elements
A cascaded dual deformable phase plate wavefront modulator enables direct AO integration with existing microscopes–doubling the aberration correction range and greatly improving image quality. Microscopy is the workhorse of contemporary…