Novel Pharmaceutical Compounds against Chagas Disease

Natural compounds with naphthalene or biphenyl substructures and interesting, pharmaceutically useful properties (e.g. naphthyl isoquinolines) have often been isolated from marine as well as terrestrial organisms in the past. They served as models for two compound classes, which are easily accessible by total synthesis and for which pronounced activities against trypanosomes have been found in cell vitality assays.

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