Compo-Q: New small molecules for the treatment of prion and neurodegenerative diseases(e.g. Alzheimer’s disease)

Scientists at the University of Duesseldorf and the University of Erlangen have developed new small molecules which can be used for the treatment of diseases characterized by the presence of misfolded

proteins. Examples for such medical conditions are prion diseases, e.g. CJD, as well as neurodegenerative (e.g. Alzheimer’s disease) or neuropsychiatric diseases. Compo-Q have a structural relationship to quinacrine which is considered to be one of the most promising candidate for the clinical therapy of prion diseases. In Compo-Q the “modified quinacrine” is covalently linked to a derivative of another substance which has been proven effective against prion diseases in vitro.

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