Genetic coding of electron spin resonance markers
Electron spin resonance (ESR) spectroscopy provides data about the structure and dynamics of large molecules and permits the examination of biologically-relevant systems, which play a role in the regulation of the expression of illness-related genes. However, magnetic markings must be affixed to strategically-selected points of protein structures, because most biological structures do not contain unpaired electrons.
At the University of Konstanz, a molecular structure and the corresponding process were developed, with which the incorporation of ESR markers into peptide structures are largely independent of existing amino acid residues. The incorporation of the markers can be done specifically in any protein structure. The peptide structure experiences no essential changes, which makes an examination using ESR spectroscopy possible in intracellular and in vivo fashion.
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