Micro fluidic system for simulating in vivo-equivalent cell barriers

In vivo like models are very important in the field of pharma- and medical research. They provide the ability to analyse complex rela-tions under defined conditions. To simulate such barrier systems it is suitable to imitate the native conditions as they occur at cell barriers in vivo. For this reason it is neces-sary to simulate in vivo cell barriers which are accessible both from the apical and the basolateral side.

The micro fluidic system according to the present invention is simulating the in vivo situation, where the cell barrier separates the compartments in two different milieus such as intestinal lumen and blood. The system comprises a container with one or more micro fluidic modules. Each module consists of two micro-structured polycar-bonate (PC) sheets separated by a trans-missible polycarbonate membrane.

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