Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Target For Insulin Found In The Heart

02.05.2003


Scientists at Bristol University have found evidence for a new protein in the heart that could one day aid development of new drugs to regulate the heart.

The ability of the heart to function as a pump that drives blood around the body depends on the electrical behaviour of muscle cells from various regions of the heart. Different cardiac regions have distinct electrical events, specialised for their particular roles in the heart.

While studying the electrical activity of heart muscle cells, doctors Jules Hancox and Yin Hua Zhang from Bristol University’’s School of Medical Sciences found that insulin activates a distinct electrical signal in cellular proteins called ’’ion channels’’. This particular electrical signal was found to be different from those of known ion channels in the heart and led them to conclude that it was likely to be from a new heart ion channel.



Defects in ion channels are known to be responsible for inherited medical conditions such as cystic fibrosis and some disorders of heart rhythm. A number of drugs used to treat heart rhythm disturbances work by affecting ion channel activity, so new targets for drugs, as well as new drugs, are constantly being sought.

Dr Hancox said: ’’Insulin has been tremendously valuable in allowing us to observe this electrical event. What is particularly exciting is that if drugs that modify the activity of this ion channel can now be found, it could in time offer a new means of regulating the heart.’’

A report describing this new effect of insulin has just been published in the international journal Circulation Research. It is hoped that further laboratory investigations will identify the new ion channel protein and provide greater insight into how its activity is controlled.

Cherry Lewis | alfa

More articles from Health and Medicine:

nachricht Clear vision – project for safer laser treatment of floaters started
26.05.2020 | Laser Zentrum Hannover e.V.

nachricht Researchers develop high-performance cancer vaccine using novel microcapsules
25.05.2020 | Chinese Academy of Sciences Headquarters

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.

researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...

Im Focus: I-call - When microimplants communicate with each other / Innovation driver digitization - "Smart Health“

Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.

When microelectronic systems are used for medical applications, they have to meet high requirements in terms of biocompatibility, reliability, energy...

Im Focus: When predictions of theoretical chemists become reality

Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.

Ultrathin materials are extremely interesting as building blocks for next generation nano electronic devices, as it is much easier to make circuits and other...

Im Focus: Rolling into the deep

Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.

A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...

Im Focus: NASA's Curiosity rover finds clues to chilly ancient Mars buried in rocks

By studying the chemical elements on Mars today -- including carbon and oxygen -- scientists can work backwards to piece together the history of a planet that once had the conditions necessary to support life.

Weaving this story, element by element, from roughly 140 million miles (225 million kilometers) away is a painstaking process. But scientists aren't the type...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

NIST researchers boost microwave signal stability a hundredfold

26.05.2020 | Physics and Astronomy

Complex genetic regulation of flowering time

26.05.2020 | Life Sciences

'One-way' electronic devices enter the mainstream

26.05.2020 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>