New Target For Insulin Found In The Heart

Scientists at Bristol University have found evidence for a new protein in the heart that could one day aid development of new drugs to regulate the heart.

The ability of the heart to function as a pump that drives blood around the body depends on the electrical behaviour of muscle cells from various regions of the heart. Different cardiac regions have distinct electrical events, specialised for their particular roles in the heart.

While studying the electrical activity of heart muscle cells, doctors Jules Hancox and Yin Hua Zhang from Bristol University’’s School of Medical Sciences found that insulin activates a distinct electrical signal in cellular proteins called ’’ion channels’’. This particular electrical signal was found to be different from those of known ion channels in the heart and led them to conclude that it was likely to be from a new heart ion channel.

Defects in ion channels are known to be responsible for inherited medical conditions such as cystic fibrosis and some disorders of heart rhythm. A number of drugs used to treat heart rhythm disturbances work by affecting ion channel activity, so new targets for drugs, as well as new drugs, are constantly being sought.

Dr Hancox said: ’’Insulin has been tremendously valuable in allowing us to observe this electrical event. What is particularly exciting is that if drugs that modify the activity of this ion channel can now be found, it could in time offer a new means of regulating the heart.’’

A report describing this new effect of insulin has just been published in the international journal Circulation Research. It is hoped that further laboratory investigations will identify the new ion channel protein and provide greater insight into how its activity is controlled.

Media Contact

Cherry Lewis alfa

Alle Nachrichten aus der Kategorie: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

Climate change drives plants to extinction in the Black Forest in Germany

Climate change is leaving its mark on the bog complexes of the German Black Forest. Due to rising temperatures and longer dry periods, two plant species have already gone extinct…

The paradox of quantum forces in nanodevices

Researchers proposed a new approach to describe the interaction of metals with electromagnetic fluctuations (i.e., with random bursts of electric and magnetic fields). Researchers from Peter the Great St.Petersburg Polytechnic…

Seasonal Forecasts Improve Food Supply

EU project CONFER started – precipitation forecasts reduce the impacts of droughts and floods in East Africa. Developing more precise seasonal forecasts to improve food supply for a total of…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close