Typ I Interferon receptor deficient mice for analysing immunological diseases

<strong>Bckground</strong><br>

Interferons play a vital role in the natural response on viral infection. In particular, type I interferon (IFN-I) is the focus of interest in the development of new therapeutic approaches for example in the fields of immunology, tumor diseases, multiple sclerosis and sepsis. </p> <strong>Technology</strong><br> Two novel transgenic mice have been developed, the IFNAR knock-out mouse (IFNARKO) and the conditional IFNAR mouse (IFNARCOND), both congenic on the C57BL/6 background, the mouse type from which most of the tumors used in tumor models are isolated. The IFNARKO mouse carries an ubiquitous deletion of the interferon type I receptor (IFNAR) allowing investigations into the role of IFNAR in every tissue and every stage of development. The conditional IFNAR-mouse allows the potential IFNAR inactivation by an adequate stimulus in a specific tissue or cell type. By this, the function of the IFN-I system can be investigated in its spatial and temporal dimensions for the first time by targeted time- and/or site-controlled IFNAR inactivation.<br><br> <p><strong>Benefits</strong> <ul> <li>Both mice are congenic (IFNARKO :20x crossed back; IFNARCOND :10x crossed back) on the C57BL/6 background (tumor mice)</li> <li>IFNARCOND based on Dupont’s Cre/loxP technology</li> <li> Big variety of transgenic mice regulating expression of the recombinase Cre in different cell types or tissues allows production of almost any kind of IFNAR deletion types.</li> </ul> <p><strong>IP Rights</strong><br> German Utility Models<br> IFNAR-KO No. 202004019129.6<br> IFNAR-COND No. 202004019128.8 </p> <p><strong>Origin</strong><br> Breeding took place at the Paul-Ehrlich-Institute (PEI) following GLP standard.</p> <p> </p>

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Contact
Dr. Dirk Dantz

Media Contact

info@technologieallianz.de TechnologieAllianz e.V.

Alle Nachrichten aus der Kategorie: Technology Offerings

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

Simplified method to modify disease signaling with light

Most diseases are caused by aberrant cell signaling processes and basic research in cell signaling is needed to identify targets for future therapeutic approaches, especially in cases where no cures…

Highly selective membranes

Researchers discover how water can affect its own filtration. Membranes with microscopic pores are useful for water filtration. The effect of pore size on water filtration is well-understood, as is…

Interactions within larger social groups can cause tipping points in contagion flow

The distribution of group interactions in a social network affects the critical point at which explosive jumps in opinion, popularity, or disease spread occur. Contagion processes, such as opinion formation…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close