Improving Bioavailability
The amidine group is an essential component of many pharmacologically active agents. However, in general pharmaceutical compositions with one or more amidine functions are almost inactive if given orally and must therefore be administered by injection. The present invention consists in a modification of at least one of the amidine functions of a pharmacological agent, resulting in its effective resorption via oral administration, followed by its conversion back into the original active form, the amidine, by the body’s own enzymes (prodrug principle).
Further Information: PDF
Patent- und Verwertungsagentur für die Wissenschaftlichen Einrichtungen in Schleswig-Holstein GmbH (PVA SH)
Phone: +49 (0)431/8009937
Contact
Dr. Alexandra Baumgartner
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Faster, more energy-efficient way to manufacture an industrially important chemical
Zirconium combined with silicon nitride enhances the conversion of propane — present in natural gas — needed to create in-demand plastic, polypropylene. Polypropylene is a common type of plastic found…
Energy planning in Ghana as a role model for the world
Improving the resilience of energy systems in the Global South. What criteria should we use to better plan for resilient energy systems? How do socio-economic, technical and climate change related…
Artificial blood vessels could improve heart bypass outcomes
Artificial blood vessels could improve heart bypass outcomes. 3D-printed blood vessels, which closely mimic the properties of human veins, could transform the treatment of cardiovascular diseases. Strong, flexible, gel-like tubes…
