PLA–Inhibitor (stoPLA) – New class of NSAIDs for oral and transdermal inflammation treatment

PLA2 enzymes exist as secreted forms and cytosolic forms. The cytosolic or cPLA2 enzymes appear to play a key role in the pathway leading to the formation of platelet activating factor and eicosanoids. PLA2 enzymes cleave phospholipids at the sn-2-position. This metabolic step isinstrumental in a variety of pathogenic processes causingpain and inflammation.

Presently glucocorticoids are used for inhibition of PLA2. Unfortunately, glucocorticoids have serious side effectswhich limit their use as medication for inflammationtreatment.

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