Novel Modulators of TRAIL Signalling Pathway

The TNF-Related Apoptosis-Inducing Ligand (TRAIL) has been shown to be involved in apoptosis, cell survival, migration and proliferation. DKFZ inventors identified a multitude of genes encoding proteins that are associated with cell death induction by TRAIL. According to its individual function, inhibition or activation of the respective gene or gene product is assumed to have beneficial effects on cancer treatment. The technology can be used to screen for small molecules, antibodies or siRNAs that are capable of modulating TRAIL-induced cell death, thus having the potential to kill cancer cells or to sensitize cancer cells to established cancer drugs.

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DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
Phone: +49-6221-42 2955

Contact
Dr. Ruth Herzog

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