Innovatives Verfahren zur industriellen Herstellung von Aptameren
Aptamers are short, single-stranded DNA molecules that can specifically bind proteins due to their three-dimensional structure.
Because of their ability to deactivate different protein functions inside the cell, aptamers are already used successfully in the field of medical diagnosis, as therapeutic agents and in environmental analytics.
So far the technical production of single stranded DNA (ssDNA) within the range of more than 60 n has been linked to a grand
percentage of abbreviated respectively functionless by-products. Bigger aptamers with even 100 n or more have only been
practicable facing great loss of quantity of material. Within the case of aptamers, an exact sequence identity is essential for
technical application, though.
By use of the described technology it is now possible to produce aptamers in the range of 100 n and beyond in unmatched quality and quantity via a multi-copy-fragment (AptaGENE), using a combination of both in vitro and in vivo techniques.
[Reference UKL221]
Further information: PDF
IMG Innovations-Management GmbH
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Dr. Klaus Kobek
As Germany's association of technology- and patenttransfer agencies TechnologieAllianz e.V. is offering businesses access to the entire range of innovative research results of almost all German universities and numerous non-university research institutions. More than 2000 technology offers of 14 branches are beeing made accessable to businesses in order to assure your advance on the market. At www.technologieallianz.de a free, fast and non-bureaucratic access to all further offers of the German research landscape is offered to our members aiming to sucessfully transfer technologies.
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