Antisense tools for functional studies of human Argonaute proteins
Specific antisense oligonucleotides were developed for the four human Argonaute proteins as non-RNAi based tools for the knockdown of human Ago expression on the mRNA and protein levels. As antisense oligonucleotides make use of RNase H based degradation of target mRNA, which is distinct from the RNAi pathway and does not interfere with RNAi or its constituents, this alternative and more unbiased antisense oligonucleotide-based approach is a choice alternative to study the biology of the different human Argonaute species as well as for the therapy of diseases based on biological processes involving Argonaute proteins on the molecular level.
Further Information: PDF
Patent- und Verwertungsagentur für die Wissenschaftlichen Einrichtungen in Schleswig-Holstein GmbH (PVA SH)
Phone: +49 (0)431/8009937
Contact
Dr. Alexandra Baumgartner
Media Contact
All latest news from the category: Technology Offerings
Newest articles
A universal framework for spatial biology
SpatialData is a freely accessible tool to unify and integrate data from different omics technologies accounting for spatial information, which can provide holistic insights into health and disease. Biological processes…
How complex biological processes arise
A $20 million grant from the U.S. National Science Foundation (NSF) will support the establishment and operation of the National Synthesis Center for Emergence in the Molecular and Cellular Sciences (NCEMS) at…
Airborne single-photon lidar system achieves high-resolution 3D imaging
Compact, low-power system opens doors for photon-efficient drone and satellite-based environmental monitoring and mapping. Researchers have developed a compact and lightweight single-photon airborne lidar system that can acquire high-resolution 3D…
