Parallel detection of phosphorylated and non-phosphorylated proteins
Phosphorylation of specific amino acid residues is the most
common posttranslational modification of proteins and has a key role in many important biological processes. The ability to detect phosphorylated and non-phosphorylated states of proteins is fundamental to research on signalling pathways and the abnormal regulatory processes underlying many diseases, for example cancer. The fluorescent dyes developed at Universität Regensburg allow the parallel detection of phosphorylated and non-phosphorylated proteins in a single step. This is achieved by a shift in the fluorescent properties of the dye on binding to phosphorylated or non-phosphorylated proteins.
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