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New animal model for sporadic Alzheimer's Disease (AD)

04.02.2011
Alzheimer's Disease (AD) is the main neurodegenerative disease worldwide. It places a large social and financial burden on society due to the need of life-long intensive care. There are two forms of AD identified by researchers, sporadic AD (SAD) and familial autosomal dominant AD (genetic background). Sporadic AD is the more common form, accounting for 90-95% of cases. Surprisingly, there is no animal model for the sporadic AD form available on the market.

Scientists of the University of Göttingen have now developed a transgenic mouse model for sporadic Alzheimer's Disease (TBA83). This is the first mouse model without any mutations showing neurological deficits by transgenic over-expressing of a particular form of amyloid beta peptides. The neurological phenotype resembles that of mouse models with neurodegeneration. We are now looking for companies, which are interested in licensing, developing and commercializing our approach.

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