Both HIV-1 and HIV-2 are of zoonotic origin , and the closest simian relatives of HIV-1 and HIV-2 have been found in the common chimpanzee (Pan troglodytes) and the sooty mangabey (Cercocebus atys) respectively. Given that humans come in frequent contact with primates in many parts of subsaharan Africa, particularly through hunting and handling primate bushmeat the possibility of additional zoonotic transfers of primate lentiviruses from species other than chimpanzees and sooty mangabeys has to be considered. This risk can only be assessed by studying the prevalence, diversity and geographic distribution of SIVinfections in wild primate populations in this part of the world.
A team of researchers from IRD and projet PRESICA working with the Ministry of Environment and Forestry from Cameroon, realized the first comprehensive survey on siv prevalences in wild caught primates from cameroon, and provide a first approximation of the magnitude and variety of sivs to which humans are exposed to through contact with non-human primates.
Nearly 800 monkeys , hunted in the rainforests, and subsequently sold for their meat on markets in Yaoundé, surrounding villages and logging concessions, or kept as pets were tested for hiv cross-reactive antibodies. Strong serological reaction, indicating infection by an SIV, was found in 16.6% of the monkeys sampled. Out of 16 species, 13 were infected. Four of these had previously not been identified as carriers of the virus. Moreover, molecular analyses showed a great diversity among the viruses present in these monkeys, and five new SIV lineages were isolated and identified. These results bring to 30 the number of monkey species liable to SIV infection and provide the first evidence that SIV is widespread and extremely diverse among wild primates in Cameroon.
This study suggests a high degree of human exposure to SIV through hunting and handling monkeys for their meat, which is a common practice in Sub-Saharan Africa. Transmission of SIVs is most likely through contact with infected blood or other secretions and possibly bites from pet animals. Bushmeat hunting is ongoing for hundreds of years, but the bushmeat trade has increased in the last decades. Commercial logging has led to road constructions, human migration, and the development of social and economic networks into remote forest areas. These socioeconomic changes, combined with our estimates of siv prevalence and genetic complexity in wild living primates, would suggest that the magnitude of human exposure to siv has increased, as have the social and environmental conditions that would be expected to support the emergence of new zoonotic infections.
Marie-Lise Sabrie | alphagalileo
Experiments in mice and human cells shed light on best way to deliver nanoparticle therapy for cancer
26.03.2020 | Johns Hopkins Medicine
Too much salt weakens the immune system
26.03.2020 | Rheinische Friedrich-Wilhelms-Universität Bonn
Together with their colleagues from the University of Würzburg, physicists from the group of Professor Alexander Szameit at the University of Rostock have devised a “funnel” for photons. Their discovery was recently published in the renowned journal Science and holds great promise for novel ultra-sensitive detectors as well as innovative applications in telecommunications and information processing.
The quantum-optical properties of light and its interaction with matter has fascinated the Rostock professor Alexander Szameit since College.
Researchers at the University of Zurich show that different stem cell populations are innervated in distinct ways. Innervation may therefore be crucial for proper tissue regeneration. They also demonstrate that cancer stem cells likewise establish contacts with nerves. Targeting tumour innervation could thus lead to new cancer therapies.
Stem cells can generate a variety of specific tissues and are increasingly used for clinical applications such as the replacement of bone or cartilage....
An international research team led by Kiel University develops an extremely porous material made of "white graphene" for new laser light applications
With a porosity of 99.99 %, it consists practically only of air, making it one of the lightest materials in the world: Aerobornitride is the name of the...
Researchers at Graz University of Technology have developed a framework by which wireless devices with different radio technologies will be able to communicate directly with each other.
Whether networked vehicles that warn of traffic jams in real time, household appliances that can be operated remotely, "wearables" that monitor physical...
Terahertz waves are becoming ever more important in science and technology. They enable us to unravel the properties of future materials, test the quality of...
26.03.2020 | Event News
23.03.2020 | Event News
03.03.2020 | Event News
27.03.2020 | Power and Electrical Engineering
27.03.2020 | Life Sciences
27.03.2020 | Life Sciences