Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Using math to kill cancer cells

14.06.2013
Here's a good reason to pay attention in math class. Nature Communications has published a paper from Ottawa researchers today, outlining how advanced mathematical modelling can be used in the fight against cancer.

The technique predicts how different treatments and genetic modifications might allow cancer-killing, oncolytic viruses to overcome the natural defences that cancer cells use to stave off viral infection.

"Oncolytic viruses are special in that they specifically target cancer cells," explains Dr. Bell, a senior scientist at the Ottawa Hospital Research Institute and professor at the University of Ottawa's Faculty of Medicine. "Unfortunately, cancer is a very complicated and diverse disease, and some viruses work well in some circumstances and not well in others. As a result, there has been a lot of effort in trying to modify the viruses to make them safe, so they don't target healthy tissue and yet are more efficient in eliminating cancer cells."

Dr. Bell and co-author Dr. Mads Kaern, an assistant professor in the University of Ottawa's Faculty of Medicine and Canada Research Chair at the University's Ottawa Institute of Systems Biology, led a team that has used mathematical modelling to devise strategies for making cancer cells exquisitely sensitive to virus infection — killing them without affecting normal, healthy cells.

"By using these mathematical models to predict how viral modifications would actually impact cancer cells and normal cells, we are able to accelerate the pace of research," says Dr. Kaern, who is also cross-appointed to the University's Department of Physics. "It allows us to quickly identify the most promising approaches to be tested in the lab, something that is usually done through expensive and time-consuming trial and error."

Drs. Bell and Kaern have established a mathematical model that described an infection cycle, including the way a virus replicated, spread and activated cellular defense mechanisms. From there, they used knowledge about key physiological differences between normal cells and cancer cells to identify how modifying the genome of the virus might counter the anti-viral defenses of cancer cells. Model simulations were remarkably accurate, with the identified viral modifications efficiently eradicating cancer in a mouse model of the disease.

"What is remarkable is how well we could actually predict the experimental outcome based on computational analysis," says Dr. Bell. "This work creates a useful framework for developing similar types of mathematical models in the fight against cancer."

The research, funded by an innovation grant from the Canadian Cancer Society, is only the beginning, explains Dr. Kaern. "We worked with a specific kind of cancer cell. We will now expand that to look at other cancer cell types and see to what degree the predictions we made in one special case can be generalized to others, and to identify strategies to target other types of cancer cells."

The findings may also help researchers better understand the interaction between these cancer cells and the virus. While one magic cure-all will likely never happen due to cancer's complexity, the researchers have developed a framework where they can learn more about the disease in the cases where the simulations don't match.

"From my perspective, that's the most interesting part," concluded Dr. Kaern. "The most fascinating thing is to challenge existing knowledge represented in a mathematical model and try to understand why these models sometimes fail. It's a very exciting opportunity to be a part of this, and I am glad that our efforts in training students in computational cell biology have resulted in such a significant advancement."

The full article, "Model-based Rational Design of an Oncolytic Virus with Improved Therapeutic Potential," was published June 14, 2013, in Nature Communications. The article's authors are: Fabrice Le Bœuf, Cory Batenchuk, Markus Vähä-Koskela, Sophie Breton, Dominic Roy, Chantal Lemay, Julie Cox, Hesham Abdelbary, Theresa Falls, Girija Waghray, Harold Atkins, David Stojdl, Jean-Simon Diallo, Mads Kaern and John Bell.

This research was supported by the Hecht Foundation/Canadian Cancer Society, Canadian Institutes of Health Research, Terry Fox Foundation, Ontario Institute for Cancer Research, Cancer Research Society and National Science and Engineering Research Council.

For more information:

Paddy Moore
Manager, Communications and Public Relations
Ottawa Hospital Research Institute
613-737-8899 x 73687
613-323-5680 (cell)
padmoore@ohri.ca
Kina Leclair
Media Relations Officer
University of Ottawa
613-562-5800 x 2529
613-762-2908 (cell)
kleclair@uOttawa.ca
About the Ottawa Hospital Research Institute (OHRI)
The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the university's Faculties of Medicine and Health Sciences. OHRI includes more than 1,700 scientists, clinical investigators, graduate students, postdoctoral fellows and staff conducting research to improve the understanding, prevention, diagnosis and treatment of human disease. Research at OHRI is supported by The Ottawa Hospital Foundation. http://www.ohri.ca

Research Bringing You Tomorrow's Health Care Today
About the University of Ottawa Faculty of Medicine
The University of Ottawa's Faculty of Medicine is nationally recognized as a leader in medical research. Through their intense research activities, the Faculty of Medicine and affiliated research institute partners have contributed significantly to the following uOttawa milestones: second highest growth rate in overall Tri-Council Funding (all programs) since 2003; second in Canada by MacLean's magazine for medical science grants; and the third highest growth rate in Canadian Institutes of Health Research (CIHR) funding for universities with medical schools since 2003.

Paddy Moore | EurekAlert!
Further information:
http://www.ohri.ca

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Quantum bugs, meet your new swatter

20.08.2018 | Information Technology

A novel synthetic antibody enables conditional “protein knockdown” in vertebrates

20.08.2018 | Life Sciences

Metamolds: Molding a mold

20.08.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>