Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tiny silicone spheres come out of the mist

07.05.2015

Technology in common household humidifiers could enable the next wave of high-tech medical imaging and targeted medicine, thanks to a new method for making tiny silicone microspheres developed by chemists at the University of Illinois.

Led by chemistry professor Kenneth Suslick, the researchers published their results in the journal Advanced Science.


Illinois chemists developed a method to make tiny silicone microspheres using misting technology found in household humidifiers. The spheres could have applications in targeted medicine and imaging.

Credit: Kenneth Suslick

Microspheres, tiny spheres as small as a red blood cell, have shown promise as agents for targeted drug delivery to tissues, as contrast agents for medical imaging, and in industrial applications.

One prime contender as a material for microspheres is silicone, the rubbery plastic found in everything from bathtub caulk to kitchenware to medical implants, but a method of making silicone into microspheres has eluded scientists.

Silicone owes its versatility to its unique combination of properties: It is biocompatible, heat resistant, chemically stable, waterproof and environmentally benign. Yet some of those same qualities have frustrated researchers attempting to make silicone microspheres.

The traditional microsphere-making method of suspending tiny droplets of material in another liquid does not work with silicone.

"For silicone, creating a stable emulsion of small droplets is very difficult," Suslick said. "Even if a stable emulsion is achieved, you run into even bigger problems when it is heated, which is necessary to polymerize into solid spheres. Upon heating, small droplets of silicone starting material will coalesce with other droplets and produce only bigger spheres."

The Illinois team uses a technique called ultrasonic spray pyrolysis, which employs technology found in household humidifiers to create a mist of ultrafine droplets. Suslick's group has pioneered the technique for a variety of materials, and teamed up with U. of I. chemistry professor Catherine Murphy to tackle the problem of silicone.

The researchers send a mist containing all the ingredients of silicone through a heated tube, which solidifies the mist into tiny spheres of silicone. Because the droplets are all separate within the mist, they don't stick together like they do in an emulsion, so the resulting microspheres are roughly 100 times smaller than any previously reported.

The researchers made silicone microspheres with a variety of properties for different applications, including colored, fluorescent and magnetic spheres. Because the spheres are bio-inert - they do not react with chemicals in the body - and the researchers believe they would be excellent vessels for extended-release pharmaceuticals. They are also exploring potential applications of solid, hollow and magnetic microspheres.

"The applications for silicone microspheres, to date, have been almost entirely speculative, simply because no one has been able to actually make them," said Jacqueline Rankin, the lead graduate student on this project. "With this new method, silicone microspheres can be easily and readily synthesized, facilitating the exploration of technologies that have only been speculated upon and creating novel technologies and new science in a number of scientific disciplines."

###

Graduate students Nitin Neelakantan, Elissa Grzincic and Kimberly Lundberg were co-authors of the paper. The work was supported by the National Science Foundation, National Institutes of Health, James R. Beck Fellowship, and the Robert C. and Carolyn J. Springborn Endowment.

Editor's note: To reach Ken Suslick, call 217-333-2794; email: ksuslick@illinois.edu.

The paper, "Magnetic, Fluorescent, and Copolymeric Silicone Microspheres," is available online at http://onlinelibrary.wiley.com/doi/10.1002/advs.201500114/full.

Media Contact

Liz Ahlberg
eahlberg@illinois.edu
217-244-1073

 @NewsAtIllinois

http://www.illinois.edu 

Liz Ahlberg | EurekAlert!

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>