Developed by biologists at Argonne National Lab
Structural changes in proteins can now be seen in increased detail, using a new application of an existing technique. The application, developed at the U.S. Department of Energys Argonne National Laboratory, could help produce lead drugs for disease therapy.
In research published in Chemistry and Biology, the scientists report the use of wide angle X-ray scattering (WAXS), an X-ray diffraction technique that has previously been used to determine the crystalline structures of polymers. The biologists adapted this materials science technique to study ligand-induced structural changes in proteins. Ligands are molecules that can cause the creation of complex compounds in protein structure. The results Argonne scientists achieved using WAXS are comparable to the already accepted predictions of protein structures provided by X-ray crystallography, and are easier and quicker to obtain. The results also show promise for using WAXS as a reliable and high-speed tool for lead drug identification.
Catherine Foster | EurekAlert!
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