Combined application of epigenetic modifiers and TALEs
The patented method enables the reactivation of epigenetically-silenced genes. The scientists have discovered a method for removing methyl groups in certain areas of the DNA, which can be used to reactivate epigenetically-silenced genes. While known transcription factors (proteins that bind to the DNA and switch a gene on via a promoter) like TALEs or zinc fingers already dock at certain gene sections of the DNA, this has not been possible up to now in the case of epigenetically-silenced gene sequences. This problem has now been solved through the addition of valproic acid (VPA 10) and a HDAC inhibitor. This measure made it possible to “open” the packaging of the epigenetically-silenced gene sequences, which consists of HDAC (histone deacetylases), making them accessible to the transcription factors.
Further Information: PDF
Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0
Contact
Peer Biskup
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Webb captures top of iconic horsehead nebula in unprecedented detail
NASA’s James Webb Space Telescope has captured the sharpest infrared images to date of a zoomed-in portion of one of the most distinctive objects in our skies, the Horsehead Nebula….
Cost-effective, high-capacity, and cyclable lithium-ion battery cathodes
Charge-recharge cycling of lithium-superrich iron oxide, a cost-effective and high-capacity cathode for new-generation lithium-ion batteries, can be greatly improved by doping with readily available mineral elements. The energy capacity and…
Novel genetic plant regeneration approach
…without the application of phytohormones. Researchers develop a novel plant regeneration approach by modulating the expression of genes that control plant cell differentiation. For ages now, plants have been the…