Interferons play a vital role in the natural response on viral infection. In particular, type I interferon (IFN-I) is the focus of interest in the development of new therapeutic approaches for example in the fields of immunology, tumor diseases, multiple sclerosis and sepsis. </p> <strong>Technology</strong><br> Two novel transgenic mice have been developed, the IFNAR knock-out mouse (IFNARKO) and the conditional IFNAR mouse (IFNARCOND), both congenic on the C57BL/6 background, the mouse type from which most of the tumors used in tumor models are isolated. The IFNARKO mouse carries an ubiquitous deletion of the interferon type I receptor (IFNAR) allowing investigations into the role of IFNAR in every tissue and every stage of development. The conditional IFNAR-mouse allows the potential IFNAR inactivation by an adequate stimulus in a specific tissue or cell type. By this, the function of the IFN-I system can be investigated in its spatial and temporal dimensions for the first time by targeted time- and/or site-controlled IFNAR inactivation.<br><br>
firstname.lastname@example.org | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.
Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
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