Plants have been suggested as potential cost-effective and safe GP-production systems; yet, major differences in the final steps of biosynthetic pathways in mammals and plants lead to different glycosylation patterns, provoking an immune response when treating humans with GPs produced in plants. On the other hand, glycosylation is a pre-requisite for proper protein folding, which in case of diagnostic and therapeutic glycoproteins should ideally not include immu-nogenic residues. Challenge State-of-the-art approaches utilize glycosylation mutants or overexpression of the desired protein product (intending to override the cellular glycosylation machinery), although such mutants either show impaired yield or loss of vitality in com-parison to wild-type plants. Also, glycan components rarely terminate in mannose residues, which is essential for uptake via mannose receptors in patients with lysosomal storage diseases. This invention provides a new tool to generate GPs with hypo-allergenic properties in a cost-effective way: In con-trast to current methods, the new technique enables effec-tive production of heterologous GPs by vital plants without impair¬¬ments. The technology is based on genetic modifica-tion of the plant glycosylation pathway.
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Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
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Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
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Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
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Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
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