Muscular dystrophies are a heterogenous group of inherited single-gene disorders, characterized clinically by progressive muscle weakness and wasting. In many cases the molecular basis of a muscular dystrophy is a disruption of the cytoskeleton - extracellular - matrix link, caused by a lack of expression of components of the dystrophin-glycoproteincomplex (DGC).
According to a current model this results in a destabilization of the entire DGC, thereby affecting the structural integrity of the muscle membrane. Duchenne muscular dystrophy (DMD), a severe X-chromosome-linked myopathy, is caused by mutations in the dystrophin gene. Nevertheless, several lines of evidence indicate that dystrophin deficiency is only the first step of a complex pathogenic cascade and much of the late pathology seems to result from ongoing cycles of muscle fiberde- and regeneration. In this respect, characterization of key control components of the de-/regeneration system would open new paths to interfere with the dystrophic process.
Further Information: PDF
Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0
email@example.com | TechnologieAllianz e.V.
Safety binding system for ski touring and telemarking
20.10.2016 | TechnologieAllianz e.V.
Enantiomerically pure chiral N-acyl-a-aminonitriles - Method for chemical production avoiding the need of toxic reagents
19.10.2016 | TechnologieAllianz e.V.
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
27.10.2016 | Materials Sciences
27.10.2016 | Physics and Astronomy
27.10.2016 | Life Sciences