Muscular dystrophies are a heterogenous group of inherited single-gene disorders, characterized clinically by progressive muscle weakness and wasting. In many cases the molecular basis of a muscular dystrophy is a disruption of the cytoskeleton - extracellular - matrix link, caused by a lack of expression of components of the dystrophin-glycoproteincomplex (DGC).
According to a current model this results in a destabilization of the entire DGC, thereby affecting the structural integrity of the muscle membrane. Duchenne muscular dystrophy (DMD), a severe X-chromosome-linked myopathy, is caused by mutations in the dystrophin gene. Nevertheless, several lines of evidence indicate that dystrophin deficiency is only the first step of a complex pathogenic cascade and much of the late pathology seems to result from ongoing cycles of muscle fiberde- and regeneration. In this respect, characterization of key control components of the de-/regeneration system would open new paths to interfere with the dystrophic process.
Further Information: PDF
Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0
email@example.com | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.
Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences