Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A Method for Restoring BMP-Receptor Signaling in a Cell

12.09.2012
<strong>Background</strong><br>

Defects in BMP signaling can cause different diseases, e.g. interruption of the BMP/cGKI (cGMP-dependent protein kinase I) pathway due to a mutation in the BMP receptor II (BRII) protein causes e.g. pulmonary artery hypertension.<br><br> <strong>Technology</strong><br>

We offer assays for the screening of compounds that are involved in the BMP-receptor signaling and are suitable for restoring BMP-Receptor signaling in a cell.<br><br> The assays uses the BMP-receptor for the screening for compounds with a high cGMP dependent protein kinase 1 activity (cGKI) or uses cGKI for screening for receptors that are associated with it. The novel cGKI-based pharmaceuticals can be used to treat a cell, tissue or an organism with a disease or a condition that is associated with impeded or interrupted BMPreceptor<br><br> signaling, insofar as the activity of cGKI is increased in the cell, tissue or organ to be treated.<br><br> Those diseases can be pulmonary artery hypertension, fibrosis, cancer, bone disease, including brachydaktyly and fractures or neurodegenerative diseases.<br><br> <p><strong>Benefits</strong> <ul> <li>Method offers an additive for restoring or enhancing BMP receptor signaling</li> <li>The in vitro/in vivo tested novel compounds are suitable for the treatment of pulmonary artery hypertension, fibrosis, cancer and bone diseases</li> </ul> <p><strong>IP Rights</strong><br> AEP application filed 02/2008<br> PCT application filed 02/2009<br> <br> <strong>Patent Owner</strong><br> Freie Universität Berlin.</p>

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Contact
Dr. Dirk Dantz

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2737&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

Leipzig HTP-Forum discusses "hydrothermal processes" as a key technology for a biobased economy

12.07.2017 | Event News

 
Latest News

Researchers create new technique for manipulating polarization of terahertz radiation

20.07.2017 | Information Technology

High-tech sensing illuminates concrete stress testing

20.07.2017 | Materials Sciences

First direct observation and measurement of ultra-fast moving vortices in superconductors

20.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>