The project is motivated by VTT's discovery of early metabolic signatures predictive of later progression to autoimmunity and type 1 diabetes. These metabolic signatures suggest the potential role of gut microbiota in early T1D pathogenesis.
Therefore, in this project the aim is to discover specific microbes or lack of them associated with later progression to T1D, and to utilize that information for developing new prevention strategies. If the tests for the prevention strategies are successful the intervention can be considered for clinical stages.
The project is initiated and coordinated by Prof. Matej Orešiè from VTT. It combines expertise in systems biology and metabolomics (VTT), clinical type 1 diabetes research (Prof. Olli Simell and his group from the Turku University Hospital and the Finnish Type 1 Diabetes Prediction and Prevention Study DIPP), and microbiology (Prof. Fredrik Bäckhed, University of Gothenburg).
The project “The gut microbiota as a novel target for prevention of type 1 diabetes” is coordinated by VTT and it is funded by the Juvenile Diabetes Research Foundation in USA.
It has been recently reported (Harjutsalo V, Sjöberg L, Tuomilehto J. Lancet. 2008;371: 1777-82) that based on current trends the incidence of type 1 diabetes in Finland will double within next 15 years and the age of onset will be younger (0-4 years). T1D is and will be therefore a major healthcare issue in Finland, and increasingly also in other Western countries. Discovery of preventive therapies capable of preventing or delaying the onset of type 1 diabetes would thus have major implications for healthcare.
Professor Matej Orešiè | VTT
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy