UT Arlington physics researchers may have developed a way to use laser technology to deliver drug and gene therapy at the cellular level without damaging surrounding tissue. The method eventually could help patients suffering from genetic conditions, cancers and neurological diseases.
In a study published recently by the journal Nature Scientific Reports, the team paired crystalline magnetic carbon nanoparticles and continuous wave near-infrared laser beams for in what is called photothermal delivery. Authors of the new paper are Ali Koymen, a professor of physics; Samarendra Mohanty, an assistant professor of physics; and Ling Gu, a researcher in Mohanty’s lab.
The new discovery grew out of previous study where Koymen and Mohanty used a 50 to 100 milliwatt laser and the same carbon nanoparticle, which absorbs the beam, to heat up and destroy cancer cells in the lab. The team used the new photothermal delivery method in lab experiments to introduce impermeable dyes and small DNA molecules into human prostate cancer and fibroblast sarcoma cells.
“In this work, Dr. Mohanty used a lower power, 20 to 30 milliwatt, continuous wave near-infrared laser and the nanoparticle to permeate the cell membrane without killing the cells. This method stretches the desired cell membrane to allow for delivery and has the added bonus of creating a fluid flow that speeds the movement of what is being delivered,” said Koymen, whose lab created the study’s crystalline magnetic carbon nanoparticle using an electric plasma discharge inside a toulene solution.
Introducing foreign DNA or other small molecules directly into cells is essential for some of the most advanced methods being developed in gene therapy, vaccinations, cancer imaging and other medical treatments. Currently, the predominant practice is using viruses for delivery to cells. Unfortunately, the scope of what can be delivered with viruses is severely limited and virus interaction can lead to inflammatory responses and other complications.
Scientists looking to create a path into the cell without employing a virus also have experimented with using UV-visible light laser beams alone. But that method damages surrounding cells and has a relatively shallow level of effectiveness.
A significant advantage of the new method is that the near-infrared light absorption of the nanoparticle can be used to selectively amplify interaction of low power laser with targeted tissue and “laser induced-damage to non-targeted cells along the irradiation path can be avoided,” the report says. The magnetic properties of the nanoparticles also mean they can be localized with an external magnetic field; therefore a smaller concentration can be used effectively.
“Research universities like UT Arlington encourage faculty and students to follow each new discovery with even deeper questions,” said Pamela Jansma, dean of the UT Arlington College of Science. “With their latest publication, Drs. Koymen, Mohanty and Gu have taken their collaboration to a new level as they keep building toward valuable implications for human health and disease treatment.”
Carbon nanoparticles produced for the cancer study varied from five to 20 nanometers wide. A human hair is about 100,000 nanometers wide. The magnetic carbon nanoparticles also are fluorescent. So, they can be used to enhance contrast of optical imaging of tumors along with that of MRI.
Mohanty’s lab is supported by funding from the National Institutes of Health and the National Science Foundation.
About UT Arlington
The University of Texas at Arlington is a comprehensive research institution and the second largest institution in The University of Texas System. The Chronicle of Higher Education ranked UT Arlington as the seventh fastest-growing public research university in 2013. U.S. News & World Report ranks UT Arlington fifth in the nation for undergraduate diversity. Visit www.uta.edu to learn more.
Physics Professor Ali Koymen, left, and Samarendra Mohanty, an assistant professor of physics, discuss their research.
The University of Texas at Arlington is an Equal Opportunity and Affirmative Action employer.
Traci Peterson | Eurek Alert!
New mechanisms uncovered explaining frost tolerance in plants
26.09.2016 | Technische Universität München
Chains of nanogold – forged with atomic precision
23.09.2016 | Suomen Akatemia (Academy of Finland)
The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.
“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...
With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.
Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...
For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.
Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...
At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.
In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...
Every three years, the plastics industry gathers at K, the international trade fair for plastics and rubber in Düsseldorf. The Fraunhofer Institute for Laser Technology ILT will also be attending again and presenting many innovative technologies, such as for joining plastics and metals using ultrashort pulse lasers. From October 19 to 26, you can find the Fraunhofer ILT at the joint Fraunhofer booth SC01 in Hall 7.
K is the world’s largest trade fair for the plastics and rubber industry. As in previous years, the organizers are expecting 3,000 exhibitors and more than...
23.09.2016 | Event News
20.09.2016 | Event News
16.09.2016 | Event News
26.09.2016 | Materials Sciences
26.09.2016 | Materials Sciences
26.09.2016 | Materials Sciences