Proteins are made from genetic material called ribonucleic acid, or RNA. Each piece of RNA is made up of alternating stretches of useful and useless genetic material called “exons” and “introns,” respectively. To make a functional protein, the cell must get rid of the introns and link the exons together in a process called splicing. To ensure that splicing occurs in an orderly fashion, many RNAs are spliced as they are being synthesized from their DNA templates (“co-transcriptionally”).
In some cases, however, the cell skips exons or stitches them together in a different order, thus producing a distinct protein. Prior studies showed that this ‘alternative splicing’ can be achieved by slowing down the transcription process enough to allow multiple introns and exons to be made before splicing occurs.
Sanjay Tyagi, Ph.D., and colleagues at UMDNJ-New Jersey Medical School used a clever new imaging technique to follow the fate of individual RNA molecules inside the cell. RNAs that follow the usual splicing rules were spliced co-transcriptionally. But for two alternatively spliced RNAs, the splicing process was delayed until transcription was complete and the RNA was floating free. Whether this synthesize-first-splice-later approach holds true for most alternatively spliced RNAs awaits future genome-wide studies.
Journalists who wish to interview investigators in this study should contact Rob Forman, UMDNJ Chief of News Services, at 973 972 7276 or firstname.lastname@example.org .
The University of Medicine and Dentistry of New Jersey (UMDNJ) is the nation's largest free-standing public health sciences university with more than 6,000 students attending the state's three medical schools, its only dental school, a graduate school of biomedical sciences, a school of health related professions, a school of nursing and its only school of public health on five campuses. UMDNJ operates University Hospital, a Level I Trauma Center in Newark, and University Behavioral HealthCare, which provides a continuum of healthcare services with multiple locations throughout the state.
Rob Forman | Newswise Science News
First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife
Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
26.10.2016 | Awards Funding
26.10.2016 | Power and Electrical Engineering
26.10.2016 | Health and Medicine