Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Splice Now or Splice Later

30.11.2011
Cells often multi-task when synthesizing and splicing RNA. But when unconventional splicing is required, they synthesize first and splice later, according to a study led by researchers at UMDNJ-New Jersey Medical School and published in Cell on November 23.

Proteins are made from genetic material called ribonucleic acid, or RNA. Each piece of RNA is made up of alternating stretches of useful and useless genetic material called “exons” and “introns,” respectively. To make a functional protein, the cell must get rid of the introns and link the exons together in a process called splicing. To ensure that splicing occurs in an orderly fashion, many RNAs are spliced as they are being synthesized from their DNA templates (“co-transcriptionally”).

In some cases, however, the cell skips exons or stitches them together in a different order, thus producing a distinct protein. Prior studies showed that this ‘alternative splicing’ can be achieved by slowing down the transcription process enough to allow multiple introns and exons to be made before splicing occurs.

Sanjay Tyagi, Ph.D., and colleagues at UMDNJ-New Jersey Medical School used a clever new imaging technique to follow the fate of individual RNA molecules inside the cell. RNAs that follow the usual splicing rules were spliced co-transcriptionally. But for two alternatively spliced RNAs, the splicing process was delayed until transcription was complete and the RNA was floating free. Whether this synthesize-first-splice-later approach holds true for most alternatively spliced RNAs awaits future genome-wide studies.

Journalists who wish to interview investigators in this study should contact Rob Forman, UMDNJ Chief of News Services, at 973 972 7276 or formanra@umdnj.edu .

The University of Medicine and Dentistry of New Jersey (UMDNJ) is the nation's largest free-standing public health sciences university with more than 6,000 students attending the state's three medical schools, its only dental school, a graduate school of biomedical sciences, a school of health related professions, a school of nursing and its only school of public health on five campuses. UMDNJ operates University Hospital, a Level I Trauma Center in Newark, and University Behavioral HealthCare, which provides a continuum of healthcare services with multiple locations throughout the state.

Rob Forman | Newswise Science News
Further information:
http://www.umdnj.edu

Further reports about: Medical Wellness RNA RNA molecule Splice UMDNJ genetic material public health

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>