"Neuregulin 3 is clearly one more gene to add to the few currently known to contribute to schizophrenia," says David Valle, M.D., director of the McKusick-Nathans Institute of Genetic Medicine at Hopkins. "There's much more to do, but we're making progress."
Schizophrenia is a varied condition with a number of symptoms not shared by all affected. This could be one reason why it's been difficult to identify genes that contribute to the condition.
To address this, the team first rigorously separated the 73 different symptoms into nine distinct factors associated with the condition—prodromal, negative, delusion, affective, scholastic, adolescent sociability, disorganization, disability, hallucination.
Then, using genetic samples from more than 450 people with schizophrenia and their parents as well as unrelated non-affected people for comparison, the team focused on one region of chromosome 10 that previously had been implicated to contain genes that contribute to the condition. They analyzed more than 1,400 single nucleotide polymorphisms, or SNPs for short, to see if any particular SNPs were more frequently carried by schizophrenia patients than unaffected people.
They found three SNPs strongly associated with delusions, and all three SNPs are located in the neuregulin 3 gene. In fact, of the team's top 20 most significant SNPs, 13 of them are located at or near this gene, but rather than being associated with delusion, the other SNPs are associated with scholastic, disorganization and hallucination factors.
"Neuregulin 3 makes sense because it's turned on mostly in the central nervous system, and the related gene neuregulin 1 also has been shown to be associated with schizophrenia," says Dimitrios Avramopoulos, M.D., Ph.D., an associate professor of psychiatry and member of the Institute of Genetic Medicine.
"We're still at the stage of trying to understand the disease, figuring out what goes wrong in the brain," says Avramopoulos who adds that the next step for this team is to follow up and sequence the neuregulin 3 gene from a number of the patients in this study to look for rare genetic variants that might also contribute to the condition.
Further reports about: > Genetic > Medicine > Negative > Neuregulin > SNP > SNPs > adolescent sociability > condition—prodromal > delusion > disorganization > genetic variant > hallucination > neuregulin 3 gene > new schizophrenia gene > related disorders > schizophrenia > scholastic > single nucleotide polymorphisms
Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel
The Nagoya Protocol Creates Disadvantages for Many Countries when Applied to Microorganisms
05.12.2016 | Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
05.12.2016 | Power and Electrical Engineering
05.12.2016 | Materials Sciences
05.12.2016 | Power and Electrical Engineering