Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Isolate Genes for Mosquito’s Sense of Smell

28.11.2001


New research is helping to unravel the machinery that allows a mosquito to sniff out its human quarry, which could lead to more and better ways of foiling the disease-spreading insects. A report published today in the online version of the Proceedings of the National Academy of Sciences describes four genes that appear to produce odor-sensing molecules in Africa’s Anopheles gambiae, a carrier of malaria, the number two killer in the developing world. Understanding how such genes operate could enable scientists to develop new compounds that will repel mosquitoes or lure them to poisons. Such chemicals are needed, senior author Laurence J. Zwiebel of Vanderbilt University explains, because "current levels of malaria and other insect-borne diseases suggest that we’re not controlling these insects very well."



Zwiebel and colleagues scanned the mosquito genome looking for genes similar to those that generate fruit fly odorant receptors, proteins that project from nerve cells and initiate a biochemical cascade when they encounter certain molecules in the air. The four candidates the team found were all active in the antennae and mouthparts of the mosquito, where its sense of smell resides. Significantly, one of the genes the team isolated was active only in females—the mosquito gender that bites—and its activity dropped off sharply 12 hours after a blood meal. Previous studies have found that a female’s sense of smell is dulled after feeding on human blood. Zwiebel says he and co-workers have now isolated a total of 30 possible receptors, and he expects to find anywhere from 60 to 100 in the end.

"Understanding the switch in the mosquito nose is just step one," he notes. Individual receptors generally bind to a range of molecules with varying strengths. A longer and more difficult task, he says, will be to figure out how a mosquito’s brain processes the signals that various receptors send. Controlling malaria will require an international effort, Zwiebel stresses, and "we hope that by identifying these sorts of genes… we’ll be able to help."

JR Minkel | Scientific American
Further information:
http://www.sciam.com/news/112701/1.html

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Satellite-based Laser Measurement Technology against Climate Change

17.01.2017 | Machine Engineering

Studying fundamental particles in materials

17.01.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>