Results Provide End-to-End Experimental Demonstration of Future DNA Sequencing Technology, Lay Groundwork for Human Re-sequencing
Solexa today announced the completion of its first genome sequence, that of the virus Phi-X 174. The company announced genome coverage of 100%, accuracy of at least 99.93% and the detection of at least three mutations subsequently confirmed by conventional DNA sequencing techniques. This accuracy was achieved despite a number of sub-sequences, which are particularly difficult to sequence with certain other chemistries.
The work reported by Solexa today was completed using its breakthrough/completely novel sequencing biochemistry. This work provides end-to-end demonstration of a technology expected to sequence the DNA of individual humans for the detection of key disease-predisposing mutations. The genome sequence has already been repeated a number of times.
Rowan Minnion | alfa
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