Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene acts as a brake on breast cancer progression

30.11.2011
Newly published research explores the role of 14-3-3ó in tumour suppression

New research out of McGill University's Goodman Cancer Research Centre provides compelling new evidence that a gene known as 14-3-3ó plays a critical role in halting breast cancer initiation and progression. The study, led by the Dept. of Biochemistry's William J. Muller, will be published online today in the journal Cancer Discovery.

The discovery of this new target points to novel therapies that eventually could slow or stop breast cancer progression. Muller also says that this gene is likely a major player in a number of other types of cancer.

Based on past clinical observations revealing that the expression of gene 14-3-3ó is silenced in a large percentage of breast cancers, researchers had long suspected that it played a role in stopping cancer cells from dividing. The McGill team wanted to confirm whether this was the case. Using a transgenic mouse model that expresses ErbB2, an oncogene associated with aggressive breast cancers, they inactivated the 14-3-3ó gene in the mammary gland.

"We found that the loss of this expression did, in fact, result in a dramatic acceleration of tumour onset," explained Muller who is also affiliated with the Research Institute of the McGill University Health Centre (RI MUHC). "The two genes, 14-3-3ó and ErbB2, co-operate, with 14-3-3ó being the brakes. If you lose the brakes, ErbB2 can induce the cells to divide indefinitely. Furthermore, not only is the ability of these cells to divide enhanced but they become extraordinarily metastatic. They can invade distant sites."

Co-authors include Chen Ling, Vi-Minh-Tri Su and Dongmei Zuo. All are from the Goodman Cancer Research Centre and McGill's Faculty of Medicine in the Dept. of Biochemistry. All authors were supported by grants from the Canadian Institutes of Health Research (CIHR) and the Terry Fox Foundation.

"We are pleased that our funding has led to a better understanding of molecular mechanisms of breast cancer development, which ultimately will lead to improved interventions for breast cancer patients " said Dr. Morag Park, the Scientific Director of the CIHR, Institute of Cancer.

The paper, Loss of the 14-3-3ó tumour suppressor is a critical event in ErbB2-mediated tumour progression, may be found here: http://cancerdiscovery.aacrjournals.org/content/early/2011/11/10/2159-8290.CD-11-0189.abstract


Contact:
Allison Flynn,
McGill Media Relations
-
Tel.: 514-398-7698

Allison Flynn | EurekAlert!
Further information:
http://www.mcgill.ca

More articles from Life Sciences:

nachricht Individual Receptors Caught at Work
19.10.2017 | Julius-Maximilians-Universität Würzburg

nachricht Rapid environmental change makes species more vulnerable to extinction
19.10.2017 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Electrode materials from the microwave oven

19.10.2017 | Materials Sciences

New material for digital memories of the future

19.10.2017 | Materials Sciences

Physics boosts artificial intelligence methods

19.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>