Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering
DKFZ together with Technical University of Denmark (DTU) developed an analogue of Griseofulvin as a compound for cancer treatment, which selectively targets cancer cells only.
Griseofulvin is a natural antibiotic produced by Penicillium griseofulvum as well as other microfungi and is still commonly used in humans for the treatment of dermatomycoses of skin, hair, and nails caused by Microsporum, Trichophyton, and Epidermophyton. Further hit to lead development of the natural compound was achieved by medicinal chemistry with corresponding biological activity tests. Advantages – drug which selectively targets cancer cells only with little effect on normal tissues – possible treatment of several cancer types – analogue of natural compound (griseofulvin, orally available, almost no side effects in humans), thoroughly studied in biological tests
Further Information: PDF
Deutsches Krebsforschungszentrum DKFZ
Phone: +49-6221-42 2955
Contact
Dr. Ruth Herzog
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Lower dose of mpox vaccine is safe
… and generates six-week antibody response equivalent to standard regimen. Study highlights need for defined markers of mpox immunity to inform public health use. A dose-sparing intradermal mpox vaccination regimen…
Efficient, sustainable and cost-effective hybrid energy storage system for modern power grids
EU project HyFlow: Over three years of research, the consortium of the EU project HyFlow has successfully developed a highly efficient, sustainable, and cost-effective hybrid energy storage system (HESS) that…
Safer alternative for an explosive reaction
The chemical industry has been using a reaction with explosive chemicals for over 100 years – now Mülheim scientists have discovered a safer alternative. The Ritter Group of the Max…