Bone Reconstruction / Fracture Healing: BMP2 Variants with Reduced BMP Antagonist Sensitivity
The novel method acts by replacing central residues and domains within BMP2 which are of prime importance for the specific interactions with its inhibitors. These alterations are aimed to convert the protein into an antagonist-resistant variant, especially against the antagonist Noggin, with increased biological activity. The modulated BMP variants are useful for fracture healing, spinal fusions and bone induction.
Further Information: PDF
ipal GmbH
Phone: +49 (0)30/2125-4820
Contact
Ursula Haufe
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Trotting robots reveal emergence of animal gait transitions
A four-legged robot trained with machine learning by EPFL researchers has learned to avoid falls by spontaneously switching between walking, trotting, and pronking – a milestone for roboticists as well…
Innovation promises to prevent power pole-top fires
Engineers in Australia have found a new way to make power-pole insulators resistant to fire and electrical sparking, promising to prevent dangerous pole-top fires and reduce blackouts. Pole-top fires pose…
Possible alternative to antibiotics produced by bacteria
Antibacterial substance from staphylococci discovered with new mechanism of action against natural competitors. Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment. Researchers…
