Important defence against stomach ulcer bacterium identified

The study was conducted in collaboration with researchers at universities in Brisbane and Melbourne and has been published in the scientific journal Public Library of Science Pathogens.

“Half of all people carry Helicobacter pylori in their bodies,” says Sara Lindén from the Sahlgrenska Academy, one of the researchers behind the study. “Many don't even notice that they have the bacterium, but some develop stomach ulcers, and in some cases the inflammation leads to stomach cancer. Our discovery may partially explain why the bacterium affects people so differently.”

The research team has shown that a protein called MUC1 found in the lining of the stomach is important for the body's defence against the bacterium. Greatly magnified, MUC1 looks like a tree growing out of low bushes on the surface of the stomach. As MUC1 is taller than the other structures on the cell surface, Helicobacter pylori readily becomes attached to the protein and then rarely gets to infect the cell.

“You could say that MUC1 acts as a decoy which prevents the bacterium from coming into close contact with the cell surface,” says Lindén. “Genetic variations between people mean that our MUC1 molecules vary in length, and this may be part of the reason why Helicobacter pylori makes some people more ill than others.”

The Research team of Sara Lindén is located at the Sahlgrenska Academy's strategic research centre MIVAC (Mucosal Immunobiology and Vaccine Center). Researchers at the centre are developing new ways of treating diseases that affect the mucus membranes.

ABOUT HELICOBACTER PYLORI
There are many different strains of the helical rod bacterium Helicobacter pylori. The bacterium has several different structures on its surface that it uses to attach to other structures rather like a space shuttle docks onto a space station. These structures look different on different strains of the bacterium.
For more information, please contact:
Sara Lindén, assistant professor, tel +46 70 981 79 79, +46 584 47 20 27, e-mail sara.linden@gu.se
Journal: Public Library of Science Pathogens
Title of article: MUC1 Limits Helicobacter pylori Infection Both by Steric Hindrance and by Acting as a Releasable Decoy

Authors: Sara K Lindén, Yong H Sheng, Alison L Every, Kim M Miles, Emma C Skoog, Timothy HJ Florin, Philip Sutton and Michael A McGuckin

Elin Lindström Claessen
Public Relations Officer at the Sahlgrenska Academy at the University of Gothenburg
Tel: +46 31 786 3869, +46 70 829 43 03
E-mail: elin.lindstrom@sahlgrenska.gu.se
The Sahlgrenska Academy is the health sciences faculty at the University of Gothenburg and conducts education and research in the fields of medicine, dentistry and care sciences. About 4,000 undergraduate and 1,000 doctoral students are enrolled at the academy, which has 1,500 employees, including 850 research and/or teaching staff.