Scientists Teach Cultured Brain Cells to Keep Time

Patterns are an essential part of timing. The human brain easily learns patterns, allowing us to recognize familiar patterns of shapes, like faces, and timed patterns, like the rhythm of a song. But exactly how the brain keeps time and learns patterns remains a mystery.

FINDINGS
In this three-year study, UCLA scientists attempted to unravel the mystery by testing whether networks of brain cells kept alive in culture could be “trained” to keep time. The team stimulated the cells with simple patterns – two stimuli separated by different intervals lasting from a twentieth of a second up to half a second.

After two hours of training, the team observed a measurable change in the cellular networks’ response to a single input. In the networks trained with a short interval, the network’s activity lasted for a short period of time. Conversely, in the networks trained with a long interval, network activity lasted for a longer amount of time.

IMPACT
The UCLA findings are the first to suggest that networks of brain cells in a petri dish can learn to generate simple timed intervals. The research sheds light on how the brain tells time and will enhance scientists’ understanding of how the brain works.
AUTHOR
Dean Buonomano, professor of neurobiology and psychology at UCLA’s David Geffen School of Medicine and Brain Research Institute, is available for interviews.
GRAPHICS
A color image showing cell-network response time is available upon request.
JOURNAL
The research appears in the June 13 edition of Nature Neuroscience, now online at http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.2579.html.
FUNDING
The study was supported by a grant from the National Institute of Mental Health.