Illinois scientists link dietary DHA to male fertility

“Normal sperm cells contain an arc-like structure called the acrosome that is critical in fertilization because it houses, organizes, and concentrates a variety of enzymes that sperm use to penetrate an egg,” said Manabu Nakamura, a U of I associate professor of biochemical and molecular nutrition.

The study shows for the first time that docosahexaenoic acid (DHA) is essential in fusing the building blocks of the acrosome together. “Without DHA, this vital structure doesn't form and sperm cells don't work,” said Timothy Abbott, a doctoral student who co-authored the study.

Men concerned about their fertility may wonder what foods contain DHA. Marine fish, such as salmon or tuna, are excellent sources of this omega-3 fatty acid.

The scientists became intrigued with DHA's role in creating healthy sperm when they experimented with “knockout” mice that lack a gene essential to its synthesis. “We looked at sperm count, shape, and motility, and tested the breeding success rate. The male mice that lacked DHA were basically infertile,” Nakamura said.

But when DHA was introduced into the mice's diet, fertility was completely restored. “It was very striking. When we fed the mice DHA, all these abnormalities were prevented,” he said.

The scientists then used confocal laser scanning (3D) microscopy to look at thin slices of tissue in progressive stages of a sperm cell's development. By labeling enzymes with fluorescence, they could track their location in a cell.

“We could see that the acrosome is constructed when small vesicles containing enzymes fuse together in an arc. But that fusion doesn't happen without DHA,” he said.

In the absence of DHA, the vesicles are formed but they don't come together to make the arch that is so important in sperm cell structure, he noted.

Nakamura finds the role this omega-3 fatty acid plays in membrane fusion particularly exciting. Because DHA is abundant in specific tissues, including the brain and the retina as well as the testes, the scientists believe their research findings could also impact research relating to brain function and vision.

“It's logical to hypothesize that DHA is involved in vesicle fusion elsewhere in the body, and because the brain contains so much of it, we wonder if deficiencies could play a role, for example, in the development of dementia. Any communication between neurons in the brain involves vesicle fusion,” he noted.

The Illinois scientists will continue to study sperm; meanwhile, Nakamura has sent some of his DHA-deficient knockout mice to other laboratories where scientists are studying DHA function in the brain and the retina.

The study was published in a recent issue of Biology of Reproduction. Co-authors are Manuel Roqueta-Rivera, Timothy L. Abbott, Mayandi Sivaguru, and Rex A. Hess, all of the U of I. The work was supported in part by a CONACyT Mexico fellowship award.

Media Contact

Phyllis Picklesimer EurekAlert!

Weitere Informationen:

http://www.illinois.edu

Alle Nachrichten aus der Kategorie: Life Sciences

Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

New materials: A toggle switch for catalysis

Electrochemical reactions, which will play an important role in the future of energy supply, can now be explained in detail, thanks to measurements carried out by TU Wien and DESY….

New approach to exotic quantum matter

While in a three-dimensional world, all particles must be either fermions or bosons, it is known that in fewer dimensions, the existence of particles with intermediate quantum statistics, known as…

Flood risks: More accurate data thanks to Covid-19

Emerging use of Global Navigation Satellite System (GNSS) makes it possible to continuously measure shallow changes in elevation of Earth surface. A study by the University of Bonn now shows…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close