New Minor-HLA for the Diagnostics, Prophylaxis and Therapy of AML Patients
T lymphocytes present HLA molecules on their surface. The allogeneic transplantations of blood cells could lead either to a required graft- versus- leukaemia/ tumor reaction (GvL/T) or could result in an undesired graft-versus-Host-Disease (GvHD). If there is a complete HLA-match, these effects could result from minor histocompatibility antigens. The present invention deals with an unknown mHAg. Studies have shown that T cells from one donor, which were coincubated with leukaemia cells (homozygous for HLA- molecules), could induce specific T cell responses. Accordingly these results refer to an immunogenic mHAg. A minor- mismatch could lead to a GvH- Disease or to positive GvL reactions. In the first case a tissue typing from donor and recipient could minimize the risk of a GvHD. In the second case the preferable GvL-/ GvT- effects could be increased through a transfer of antigen specific T cells or T cell receptors by inoculation.
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