Manipulation of the growth of living cells via cell-surface-interaction

Scientists of Saarland University have developed a setup, which allows a controlled manipulation of cells via cell‐surface‐interaction. Therefore biocompatible magnetic nanoparticles are functionalized with biomolecules, which in turn are able to bind specific cell types. These particles are immobilized on a magnetic substrate as well and the complex can be placed in any kind of cell culture vessel. Influenced by external magnetic fields, domain structures are formed by the complex. These domains can be changed at any time during cell cultivation through external fields as the immobilized particles follow those changes due to their magnetic interaction. The setup is computer‐controlled and allows to observe the cell behaviour over several days. Moreover a direct reaction to this is possible by manipulating the domain structure via external magnetic fields.

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Universität des Saarlandes Wissens- und Technologietransfer GmbH PatentVerwertungsAgentur der saarländischen Hochschulen
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Dipl.-Kfm. Axel Koch (MBA), Dr. Conny Clausen, Dr. Hauke Studier, Dr. Susanne Heiligenstein