DNA-binding MLW Protein for Specific – Gene Targeting
One of the most important requirements for efficient and specific gene targeting is delivering the nucleic acids to the site of interest and keeping them there until editing through the host repair machinery. Although, it is possible to deliver proteins and peptides to specific organelles and DNA regions, it is not possible to deliver nucleic acids to defined genomic DNA regions.
The present invention allows for overcoming this problem by the innovative MLW technology. MLW is a protein, wherein M specifically binds to a donor DNA sequence and W binds to a target DNA sequence. Thereby the donor and target DNA can be brought to close proximity and are immediately available for recombination.
Further Information: PDF
PROvendis GmbH
Phone: +49 (0)208/94105 10
Contact
Dipl.-Ing. Alfred Schillert
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Microscopic basis of a new form of quantum magnetism
Not all magnets are the same. When we think of magnetism, we often think of magnets that stick to a refrigerator’s door. For these types of magnets, the electronic interactions…
An epigenome editing toolkit to dissect the mechanisms of gene regulation
A study from the Hackett group at EMBL Rome led to the development of a powerful epigenetic editing technology, which unlocks the ability to precisely program chromatin modifications. Understanding how…
NASA selects UF mission to better track the Earth’s water and ice
NASA has selected a team of University of Florida aerospace engineers to pursue a groundbreaking $12 million mission aimed at improving the way we track changes in Earth’s structures, such…
