Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Application of Nanocarriers for the Treatment of Copper-deficiency Diseases

12.09.2012
</a><strong>Background</strong><br>

For several human diseases that are associated with a disturbed cellular metal-ion homeostasis, nanocarriers offer a possibility to bypass the metal-ion uptake system and thereby to rescue the effects of cellular deficiencies. The disadvantage of conventional carriers with limited matrix compatibility is that they either transport non-polar molecules into an aqueous environment or they transfer polar molecules into a hydrophobic environment (micelle). To overcome these problems of solubility and stability of active agents, nanocompartments are needed, that are compatible with various environ-ments.<br><br> <strong>Technology</strong><br> The invention offers a novel application of nanocarriers in copper-deficiency diseases, such as Alzheimer’s and Parkinson Disease. The nano-transport system can deliver copper and other divalent metal-ions with a high specifici-ty. The nanocarriers are formed by covalent modification of dendritic macro-molecules with a shell, to form stable micelle-type structures.<br><br>

<b>Benefits:</b><ul> <li>Nanocarriers with dendritic core and multishell architecture: suitable for non-covalent encapsulation of various guest molecules, compatible with different environments, targeting the nucleus across cell membranes </li> <li>Transport via passage of the blood-brain barrier in a living individual seems to be possible.</li> <li>Bypassing the cellular metal-ion uptake system to rescue the effects of Copper deficiency in certain diseases, such as Alzheimer‘s and Parkinson Diseases.</li> <li>Also diseases associated with other divalent metal ion deficiencies, e.g. Zinc, could be targeted.</li> </ul> <p><strong>IP Rights</strong><br> European patent granted in 2011<br> validated in: DE, CH, DK, ES, FR; GB, IE, IT LI, NL<br> US patent application filed in 02/2008 <br><br> <strong>Patent Owner</strong><br> Freie Universität Berlin

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Contact
Dr. Dirk Dantz

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2861&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Ten-year anniversary of the Neumayer Station III

The scientific and political community alike stress the importance of German Antarctic research

Joint Press Release from the BMBF and AWI

The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...

Im Focus: Ultra ultrasound to transform new tech

World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles

The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.

Im Focus: Flying Optical Cats for Quantum Communication

Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.

In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...

Im Focus: Nanocellulose for novel implants: Ears from the 3D-printer

Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.

It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:

Im Focus: Elucidating the Atomic Mechanism of Superlubricity

The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.

One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Our digital society in 2040

16.01.2019 | Event News

11th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Aachen, 3-4 April 2019

14.01.2019 | Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

 
Latest News

Additive manufacturing reflects fundamental metallurgical principles to create materials

18.01.2019 | Materials Sciences

How molecules teeter in a laser field

18.01.2019 | Life Sciences

The cytoskeleton of neurons has been found to be involved in Alzheimer's disease

18.01.2019 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>