“Structures built from a very large number of units can exhibit sharp transitions from one state to another state, which physicists call phase transitions,” said Cowan, a Professor in Mathematics and Neurology at Chicago. “Strange and interesting things happen in the neighborhood of a phase transition.”
When liquids undergo phase transitions, they evaporate into gas or freeze into ice. When the brain undergoes a phase transition, it moves from random to patterned activity. “The brain at rest produces random activity,” Cowan said, or what physicists call “Brownian motion.”
Although the bulk of his work involves deriving equations, Cowan’s findings mesh well with laboratory data generated on the cerebral cortex and electroencephalograms. His latest findings show that the same mathematical tools physicists use to describe the behavior of subatomic particles and the dynamics of liquids and solids can now be applied to understanding how the brain generates its various rhythms.
These include the delta waves generated during sleep, the alpha waves of the visual brain, and the gamma waves, discovered during the last decade, which seem related to information processing. “The resting state of brain activity seems to have a statistical structure that’s characteristic of a certain kind of phase transition,” Cowan said. “The brain likes to sit there because that’s the place where information processing is optimized.”
Cowan organized a session for AAAS on Mathematics and the Brain, which will take place from 8:30 to 10 a.m. EST Saturday, Feb. 16. He also will participate in a news briefing on the topic at 3 p.m. EST Friday, Feb. 15. Joining him at both events will be mathematician Nancy Kopell of Boston University and computational neuroscientist Tomaso Poggio of the Massachusetts Institute of Technology.
At this stage of his research, Cowan said it would be premature and speculative for him to try to relate how phase transitions in the brain might relate to neurological conditions or states of human consciousness. “That’s for the future,” he said.
Another component of his latest research is the close relationship between spontaneous pattern formation in brain circuits and in chemical reaction networks. In this research, he shows how mathematics can help explain visual hallucinations and how the visual cortex obtained its stripes, which are visible to the naked eye when removed from cadavers.
“This line of research on pattern formation can be traced back to Alan Turing, who also founded the modern science of computation,” said Terrence Sejnowski of the Salk Institute for Biological Studies in La Jolla, Calif., who is a leading specialist in computational neurobiology.
Cowan’s quest to understand the brain’s workings using numerical methods spans more than four decades. Along the way he has collaborated with a series of Ph.D. students and colleagues in physics, mathematics, biology and neuroscience.
In 1972, he and postdoctoral fellow Hugh Wilson, now of Canada’s York University, formulated a set of equations that could describe the dynamics of neural networks. Now called “Wilson-Cowan equations,” they became a mainstay of neural network research. “But I always knew that those equations were inadequate, so I kept thinking about them,” Cowan said.
Then in 1985, he ran across an article in a Japanese journal that described a statistical physics approach to chemical reaction networks. “It took me years to understand how to use these tools for biological networks,” he said. “It so happens that there is an analogy between the behavior of chemical reaction networks and neural networks.”
His research career began in 1962, when as a graduate student in electrical engineering, he worked with the founders of neural network theory. These included Norbert Wiener, who died in 1964, before they could work jointly on the problem that Cowan continues to address.
“I didn’t really understand what he was saying to me until I worked it out myself. He was one of the great mathematicians of the 20th century,” Cowan said.
Steve Koppes | EurekAlert!
Unraveling the nature of 'whistlers' from space in the lab
15.08.2018 | American Institute of Physics
Early opaque universe linked to galaxy scarcity
15.08.2018 | University of California - Riverside
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
15.08.2018 | Physics and Astronomy
15.08.2018 | Earth Sciences
15.08.2018 | Physics and Astronomy