Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Smart Anticancer "Nanofiber Mesh"

03.07.2013
A MANA research team has developed a new nanofiber mesh which is capable of simultaneously realizing thermotherapy (hyperthermia) and chemotherapy (treatment with anticancer drugs) of tumors. They succeeded in efficiently inducing natural death (apoptosis) of epithelial cancer cells.

Success in Inducing Natural Death of Epithelial Cancer Cells by Simultaneously Realizing Thermotherapy and Chemotherapy


Cancer treatment using the nanofiber mesh with self-heating/anticancer drug release functions.

A research team headed by Dr. Mitsuhiro Ebara, a MANA Scientist of the Biomaterials Unit (Unit Director: Takao Aoyagi) of the International Center for Materials Nanoarchitectonics (Director-General: Masakazu Aono), National Institute for Materials Science (President: Sukekatsu Ushioda) developed a new nanofiber mesh which is capable of simultaneously realizing thermotherapy (hyperthermia) and chemotherapy (treatment with anticancer drugs) of tumors. Using this nanofiber mesh, the team succeeded in efficiently inducing natural death (apoptosis) of epithelial cancer cells.

Squamous cell carcinoma (SCC) is an epithelial malignant tumor, and is found in many tissues. For example, SCC is thought to account for more than 90% of esophageal cancers, more than 80% of the cervical cancers, and more than 30% of lung cancers.

Although surgery, radiation therapy, and chemotherapy are now three main therapeutic methods according to the stages of cancers, in addition to these methods, thermotherapy has also attracted great attention in recent years. This is because it is possible to induce extinction of cancer cells by heat, as cancer cells are relatively susceptible to heat in comparison with normal cells. It has also been found that thermotherapy enhances the effect of anticancer drugs when used in conjunction with chemotherapy. However, when actually applying thermotherapy and administering anticancer drugs, the two independent therapies must be applied separately, and until now, precise control to realize treatment at the same time and same location had been difficult.

In this research, the team led by Dr. Ebara overcame this problem and succeeded in development of a method for simultaneously performing thermotherapy and chemotherapy of epithelial malignant tumors. The team developed a mesh material which is applied directly to the affected part, and is a hybrid material that combines a temperature-responsive polymer, magnetic nanoparticles, and anticancer drugs.
Although magnetic thermotherapy techniques which administer magnetic nanoparticles directly in the body have been developed previously, the difficulty of handling nanoparticles and the concerns regarding the safety of the magnetic nanoparticles themselves are the problems. The developed nanofiber mesh is easy to handle and can also be used in endoscopic surgery, etc. Moreover, because the magnetic particles contained in the fibers exist stably, diffusion in the body is minimized. For this reason, the developed method is considered to offer higher safety in comparison with methods in which magnetic particles are administered directly.

As the nanofiber mesh contains magnetic nanoparticles, which are a self-heating substance, it is possible to heat the fibers by applying an alternating magnetic field. Furthermore, the temperature-responsive polymer contracts in response to the heat generated by the magnetic nanoparticles, enabling release of the anticancer drugs contained in the nanofiber mesh. When the anticancer activity of this fiber was investigated using a human melanoma cell strain, it was found that ON-OFF control of inducement of apoptosis of the cancer cells was possible by applying an alternating magnetic field.
In 21st century, time-space control of the treatment of diseases is required. That is, it should be possible to administer drugs, etc. at an arbitrary timing and location. Because the newly-developed nanofiber mesh enables simultaneous ON-OFF control of heating of the affected part and drug release, simply by applying an external stimulus, it is considered to be a major advance in the development of next-generation therapeutic materials for 21st century medicine.

Journal information
This research achievement had been announced in the online bulletin of the scientific journal "Advanced Functional Materials" on June 14, 2013.

Mikiko Tanifuji | Research asia research news
Further information:
http://www.nims.go.jp/eng/news/press/2013/06/p201306140.html
http://www.researchsea.com

More articles from Health and Medicine:

nachricht Why might reading make myopic?
18.07.2018 | Universitätsklinikum Tübingen

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>