Initial vaccine tested in model looks promising
An experimental plague vaccine proved 100 percent effective when tested in a new mouse model for plague infection developed by scientists at Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. The scientists developed their model to mimic the natural transmission route of bubonic plague through the bites of infected fleas. The flea-to-mouse model provides a more realistic test setting than previously used methods, enabling a better assessment of a vaccines ability to protect against a real-world challenge.
The new report, authored by lead researcher and RML plague expert B. Joseph Hinnebusch, Ph.D., appears in the April edition of Infection and Immunity, now available online. Collaborators included Clayton O. Jarrett, M.S., and Florent Sebbane, Ph.D., of RML in Hamilton, MT; and Jeffrey J. Adamovicz, Ph.D., and Gerard P. Andrews, Ph.D., of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), where the recombinant plague vaccine tested in the model was made.
Ken Pekoc | EurekAlert!
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