Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer could be caught before it develops

20.06.2003


An article published in the journal BMC Medical Informatics and Decision Making describes the creation of the first comprehensive listing and classification of precancers, drawn from the medical literature. Using this classification, the precancers have been organized into groups that share similar biologic profiles and, hopefully, similar treatments.



Precancers precede invasive cancers. They are localized changes in tissue – lesions - identifiable by their morphologic structure. During carcinogenesis, when normal cells are transformed into cancerous cells, it is possible to identify precancers. Treating or removing precancerous cells at this early stage could prevent the prolonged, painful treatment and deaths of cancer sufferers. According to the authors of the article,

”Premalignant lesions are arguably the most important disease entities of modern man. In theory, the successful treatment of precancers would result in the eradication of most human cancers.”


Despite their importance, until now there has been no attempt to produce a list of precancers, or to classify them according to their biological properties. Jules Berman of the National Cancer Institute at the NIH, and Donald Henson of George Washington University, Washington D.C., have produced a first draft of such a classification, which can be downloaded from http://65.222.228.150/jjb/presum.tar.gz.

Berman and Henson worked from the National Library of Medicine’s Unified Medical Language System (UMLS), extracting all of the terms relating to precancers from the ‘Metathesaurus’, and adding an additional 10% from their own knowledge. They identified 568 distinct precancer ‘concepts’, which have been described by over 4700 terms. Often one precancer is described in many different ways, and can have a number of terms that refer to it. The database includes terms from seven languages in addition to English terms.

Precancer concepts and their associated terms were then grouped into six classes, defined by the authors, according to their biological properties. Berman and Henson provide, in the journal article, an in-depth description of precancer, along with the typical characteristics of each class of precancer.

The classification is designed to be fully searchable and linked to other databases. Written in XML (eXtensible Mark-up Language), it was converted into a HTML file so that it can be viewed in a standard Internet browser.

The authors recognize that this first draft is by no means definitive, so have posted the classification publicly and invited review by the medical community

Grace Baynes | alfa
Further information:
http://www.biomedcentral.com/1472-6947/3/8/

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Air pollution leads to cardiovascular diseases

21.08.2018 | Ecology, The Environment and Conservation

Researchers target protein that protects bacteria's DNA 'recipes'

21.08.2018 | Life Sciences

A paper battery powered by bacteria

21.08.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>