Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Combination antibody therapy results in long-term viral suppression in HIV infection

27.09.2018

A new generation of broadly neutralising antibodies provides a novel approach to treating HIV infection. The research group of Prof Florian Klein, Director of the Institute of Virology at the University Hospital Cologne and scientist at the German Center for Infection Research (DZIF), has collaborated with scientists at the Rockefeller University in New York and the University Hospital Cologne to investigate the impact of combining such antibodies in HIV-infected patients. Two articles on the results of this clinical trial have now been published in Nature and Nature Medicine.

Antiretroviral drugs are the critical component for effective management of HIV infection. Because of the rapid development of viral resistance against single agents, these drugs need to be administered in combination. While the currently approved drugs are highly active inhibitors of viral replication, they require daily and life-long dosing.


Univ.-Prof. Dr. Florian Klein, Uniklinik Köln

Uniklinik Köln


Dr. Henning Grüll, Uniklinik Köln

Uniklinik Köln

Compared to antiretroviral drugs, broadly neutralising antibodies have longer half-lives and can directly target the virus. In previous clinical trials conducted with participation of the University Hospital Cologne, two of these antibodies, called 3BNC117 and 10-1074, were administered individually.

Both antibodies were well tolerated and resulted in significant reductions of the viral load. However, similar to treatment with classical antiretroviral drugs, the administration of a single antibody had only transient effects on the viral load and was associated with the development of viral resistance.

In the current study, the scientists investigated the administration of the combination of the antibodies 3BNC117 and 10-1074 in a total of 30 HIV-infected individuals. Antibody infusions, administered up to three times per individual, were well tolerated by all study participants. In the group of HIV-infected participants who were not taking antiretroviral drugs at the start of the trial, the antibody combination resulted in substantial reductions of the viral load.

In a second group, the antibody combination was administered to individuals who paused their previous treatment with regular antiretroviral drugs. While this interruption usually results in a rapid return of HIV to the blood, no viremia was detectable in many study participants for several months after the last infusion of the antibody combination.

“The results of this clinical trial highlight the potential for antibody combinations to maintain long-term control of HIV,” says Dr Henning Grüll, co-first author of both publications and resident physician at the Institute of Virology of the University Hospital Cologne. Based on the results of the current study that was conducted in collaboration with the Rockefeller University (Prof Michel Nussenzweig; Prof Marina Caskey), novel approaches for antibody-mediated therapy of HIV infection are under consideration that could allow for long-term control of the virus without the need for daily medication.

“The success of these studies at the University Hospital Cologne is also a result of the close collaboration with the Infectious Diseases Research Group (led by Prof Gerd Fätkenheuer) and the Infectious Diseases Outpatient Clinic (led by Dr Clara Lehmann). We are delighted that we were again able to safely and rapidly translate findings from basic research into clinical application”, says Florian Klein, principal investigator of the study in Germany.

Further clinical trials investigating additional approaches to using broadly neutralising antibodies in HIV infection are currently being conducted at the DZIF site in Cologne.

Original publications
Pilar Mendoza*, Henning Gruell*, Lilian Nogueira, Joy A. Pai, Allison L. Butler, Katrina Millard, Clara Lehmann, Isabelle Suárez, Thiago Y. Oliveira, Julio C.C. Lorenzi, Yehuda Z. Cohen, Christoph Wyen, Tim Kümmerle, Theodora Karagounis, Ching-Lan Lu, Lisa Handl, Cecilia Unson-O’Brien, Roshni Patel, Carola Ruping, Maike Schlotz, Maggi Witmer-Pack, Irina Shimeliovich, Gisela Kremer, Eleonore Thomas, Kelly E. Seaton, Jill Horowitz, Anthony P. West Jr., Pamela J. Bjorkman, Georgia D. Tomaras, Roy M. Gulick, Nico Pfeifer, Gerd Fätkenheuer, Michael S. Seaman, Florian Klein*, Marina Caskey*, Michel C. Nussenzweig*
Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Nature 27 September 2018
Doi: 10.1038/s41586-018-0531-2

Yotam Bar-On*, Henning Gruell*, Till Schoofs, Joy A. Pai, Lilian Nogueira, Allison L. Butler, Katrina Millard, Clara Lehmann, Isabelle Suárez, Thiago Y. Oliveira, Theodora Karagounis, Yehuda Z. Cohen, Christoph Wyen, Stefan Scholten, Lisa Handl, Shiraz Belblidia, Juan P. Dizon, Jörg J. Vehreschild, Maggi Witmer-Pack, Irina Shimeliovich, Kanika Jain, Kerstin Fiddike, Kelly E. Seaton, Nicole L. Yates, Jill Horowitz, Roy M. Gulick, Nico Pfeifer, Georgia D. Tomaras, Michael S. Seaman, Gerd Fätkenheuer, Marina Caskey*, Florian Klein*, Michel C. Nussenzweig*
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals
Advance Online Publication (AOP) on Nature Medicine's website 26 September 2018
Doi: 10.1038/s41591-018-0186-4

Wissenschaftliche Ansprechpartner:

Prof Florian Klein
University Hospital Cologne and the DZIF
T +49 221 478 89693
E-mail: florian.klein@uk-koeln.de

Originalpublikation:

Advance Online Publication (AOP) on Nature Medicine's website 26 September 2018
Doi: 10.1038/s41591-018-0186-4

Christoph Wanko | idw - Informationsdienst Wissenschaft
Further information:
http://www.uk-koeln.de/

More articles from Health and Medicine:

nachricht Diabetes mellitus: A risk factor for early colorectal cancer
27.05.2020 | Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg

nachricht Ultra-thin fibres designed to protect nerves after brain surgery
27.05.2020 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Biotechnology: Triggered by light, a novel way to switch on an enzyme

In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".

Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...

Im Focus: New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.

researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...

Im Focus: I-call - When microimplants communicate with each other / Innovation driver digitization - "Smart Health“

Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.

When microelectronic systems are used for medical applications, they have to meet high requirements in terms of biocompatibility, reliability, energy...

Im Focus: When predictions of theoretical chemists become reality

Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.

Ultrathin materials are extremely interesting as building blocks for next generation nano electronic devices, as it is much easier to make circuits and other...

Im Focus: Rolling into the deep

Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.

A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

New 5G switch provides 50 times more energy efficiency than currently exists

27.05.2020 | Information Technology

Return of the Blob: Surprise link found to edge turbulence in fusion plasma

27.05.2020 | Physics and Astronomy

Upwards with the “bubble shuttle”: How sea floor microbes get involved with methane reduction in the water column

27.05.2020 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>