Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A holistic approach catches eye disease early

11.10.2013
An automated assessment of multiple datasets using artificial intelligence accurately diagnoses a common cause of blindness

Pathological myopia is a condition characterized by severe, progressive nearsightedness caused by the protrusion of pigmented tissue from the back of the eye.

The disease is one of the leading causes of blindness worldwide and the leading cause in Asian countries. Early diagnosis is essential for preventing permanent loss of vision but heavily relies on manual screening and involves a complete eye exam, which can take up to an hour.

Zhuo Zhang of the A*STAR Institute for Infocomm Research in Singapore and her colleagues have now developed an automated, computer-assisted informatics method that uses artificial intelligence to diagnose the condition accurately1.

In earlier work, Zhang and her colleagues developed an algorithm that could extract information about tissue texture from biomedical images of the back of the eye, or fundus, and use it to detect pathological myopia with an accuracy of 87.5%. They then showed that combining the images with demographic data such as age, sex and ethnicity, improved the accuracy further.

The latest automated method — Pathological Myopia diagnosis through Biomedical and Image Informatics (PM-BMII) — takes the process one step further; it uses an artificial intelligence approach known as multiple kernel learning to fuse the demographic data and clinical fundus images with genomic information and then analyze the combined datasets (see image).

Zhang and her colleagues tested the method on data collected from 2,258 patients, 58 of whom had already been diagnosed with pathological myopia. They found that the method could detect the condition with a high degree of accuracy and that the combination of all three datasets was more accurate than any one alone or any two combined.

Combining the three datasets probably produced the best results because each set contains different information that complements the other sets, therefore providing a holistic assessment of the disease.

The researchers suggest that the method could also be applied to the detection of other eye diseases, “including age-related macular degeneration and glaucoma. These diseases have common characteristics,” says Zhang. “They result from both environmental and genetic risk factors, and can be observed from fundus images.”

Zhang adds that it is still unclear whether adding additional types of data to the analyses would improve the accuracy of the diagnoses. “More types of data may introduce complexity into the computational model, so we cannot draw the conclusion that accuracy would be improved without further investigation.”

The A*STAR-affiliated researchers contributing to this research are from the Institute for Infocomm Research

Journal information

Zhang, Z., Xu, Y., Liu, J., Wong, D. W. K., Kwoh, C. K. et al. Automatic diagnosis of pathological myopia from heterogeneous biomedical data. PLoS ONE 8, e65736 (2013).

A*STAR Research | Research asia research news
Further information:
http://www.a-star.edu.sg
http://www.researchsea.com

More articles from Health and Medicine:

nachricht The Anticipation of Events in Time
20.01.2020 | Max-Planck-Institut für empirische Ästhetik

nachricht Mutations in donors' stem cells may cause problems for cancer patients
17.01.2020 | Washington University School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Programmable nests for cells

KIT researchers develop novel composites of DNA, silica particles, and carbon nanotubes -- Properties can be tailored to various applications

Using DNA, smallest silica particles, and carbon nanotubes, researchers of Karlsruhe Institute of Technology (KIT) developed novel programmable materials....

Im Focus: Miniature double glazing: Material developed which is heat-insulating and heat-conducting at the same time

Styrofoam or copper - both materials have very different properties with regard to their ability to conduct heat. Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz and the University of Bayreuth have now jointly developed and characterized a novel, extremely thin and transparent material that has different thermal conduction properties depending on the direction. While it can conduct heat extremely well in one direction, it shows good thermal insulation in the other direction.

Thermal insulation and thermal conduction play a crucial role in our everyday lives - from computer processors, where it is important to dissipate heat as...

Im Focus: Fraunhofer IAF establishes an application laboratory for quantum sensors

In order to advance the transfer of research developments from the field of quantum sensor technology into industrial applications, an application laboratory is being established at Fraunhofer IAF. This will enable interested companies and especially regional SMEs and start-ups to evaluate the innovation potential of quantum sensors for their specific requirements. Both the state of Baden-Württemberg and the Fraunhofer-Gesellschaft are supporting the four-year project with one million euros each.

The application laboratory is being set up as part of the Fraunhofer lighthouse project »QMag«, short for quantum magnetometry. In this project, researchers...

Im Focus: How Cells Assemble Their Skeleton

Researchers study the formation of microtubules

Microtubules, filamentous structures within the cell, are required for many important processes, including cell division and intracellular transport. A...

Im Focus: World Premiere in Zurich: Machine keeps human livers alive for one week outside of the body

Researchers from the University Hospital Zurich, ETH Zurich, Wyss Zurich and the University of Zurich have developed a machine that repairs injured human livers and keep them alive outside the body for one week. This breakthrough may increase the number of available organs for transplantation saving many lives of patients with severe liver diseases or cancer.

Until now, livers could be stored safely outside the body for only a few hours. With the novel perfusion technology, livers - and even injured livers - can now...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

„Advanced Battery Power“- Conference, Contributions are welcome!

07.01.2020 | Event News

 
Latest News

Molecules move faster on a rough terrain

20.01.2020 | Physics and Astronomy

Spider-Man-style robotic graspers defy gravity

20.01.2020 | Physics and Astronomy

Laser diode emits deep UV light

20.01.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>