Standard toxicity testing is inadequate to assess the safety of a new technology with potential for creating pesticides and genetically modifying crops, according to a Forum article published in the August issue of BioScience.
The authors of the article, Jonathan G. Lundgren and Jian J. Duan of the USDA Agricultural Research Service, argue that pesticides and insect-resistant crops based on RNA interference, now in exploratory development, may have to be tested under elaborate procedures that assess effects on animals' whole life cycles, rather than by methods that look for short-term toxicity.
RNA interference is a natural process that affects the level of activity of genes in animals and plants. Agricultural scientists have, however, successfully devised artificial "interfering RNAs" that target genes in insect pests, slowing their growth or killing them. The hope is that interfering RNAs might be applied to crops, or that crops might be genetically engineered to make interfering RNAs harmful to their pests, thus increasing crop yields.
The safety concern, as with other types of genetic modification and with pesticides generally, is that the artificial interfering RNAs will also harm desirable insects or other animals. And the way interfering RNA works means that simply testing for lethality might not detect important damaging effects. For example, an interfering RNA might have the unintended effect of suppressing the action of a gene needed for reproduction in a beneficial species. Standard laboratory testing would detect no harm, but there could be ecological disruption in fields because of the effects on reproduction.
Lundgren and Duan suggest that researchers investigating the potential of interference RNA pesticides create types that are designed to be unlikely to affect non-target species. They also suggest a research program to evaluate how the chemicals move in real-life situations. If such steps are taken, Lundgren and Duan are optimistic that the "flexibility, adaptability, and demonstrated effectiveness" of RNA interference technology mean it will have "an important place in the future of pest management."
BioScience, published monthly, is the journal of the American Institute of Biological Sciences (AIBS; http://www.aibs.org). BioScience is a forum for integrating the life sciences that publishes commentary and peer-reviewed articles. The journal has been published since 1964. AIBS is a meta-level organization for professional scientific societies and organizations that are involved with biology. It represents nearly 160 member societies and organizations. The article by Lundgren and Duan can be accessed ahead of print as an uncorrected proof at http://www.aibs.org/bioscience-press-releases/ until early August.
The complete list of peer-reviewed articles in the August 2013 issue of BioScience is as follows. These are now published ahead of print.Improving Ocean Management through the Use of Ecological Principles and Integrated Ecosystem Assessments.
Melissa M. Foley, Matthew H. Armsby, Erin E. Prahler, Margaret R. Caldwell, Ashley L. Erickson, John N. Kittinger, Larry B. Crowder, and Phillip S. LevinHow Far Are Stem-Cell-derived Erythrocytes from the Clinical Arena?
Martha F. Hoopes, David M. Marsh, Karen H. Beard, Nisse Goldberg, Alberto Aparicio, Annie Arbuthnot, Benjamin Hixon, Danelle Laflower, Lucas Lee, Amanda Little, Emily Mooney, April Pallette, Alison Ravenscraft, Steven Scheele, Kyle Stowe, Colin Sykes, Robert Watson, and Blia YangRNAi-based Insecticidal Crops: Potential Effects on Nontarget Species.
Jason W. Karl, Jeffrey E. Herrick, Robert S. Unnasch, Jeffrey K. Gillan, Erle C. Ellis, Wayne G. Lutters, and Laura J. Martin
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