Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Umeå researchers solve long-standing riddle: Show what enzyme copies genes

12.07.2007
For the first time, it can now be shown what enzyme copies the genetic make-up of cells. The discovery is being published in the journal Science by researchers at Umeå University in Sweden in collaboration with a team in the U.S. led by Thomas A. Kunkel.

The human genome has already been mapped, as have the genomes of several other organisms. On the other hand, little has been known how genes are copied and repaired so efficiently and precisely. These processes always involve a so-called DNA polymerase, an enzyme that performs the actual new growth of genes.

The genes consist of two DNA strands, but scientists have not known what polymerase copies the two DNA strands. It has been known, however, that DNA polymerase epsilon is responsible for a great deal of this synthesis in higher organisms, and that it does so with the greatest precision.

The researchers describe in the article how they mutated DNA polymerase epsilon, creating an enzyme that makes a particular error when it copies genes. This means that the enzyme leaves a signature at all sites where it copies the genes in the cell.

... more about:
»DNA »Epsilon »Polymerase »Strand »enzyme

By reading where this signature is left, the scientists have then been able to determine that DNA polymerase epsilon copies one of the strands, the so-called "leading" strand. For decades researchers have been wondering what enzyme synthesizes this particular part, and now proof has been found.

These research findings, which describe fundamental biological functions, pave the way for an enhanced understanding of how mutations occur in genes, mutations that can lead to cancer, for instance.

Contributors from Umeå University are Erik Johansson, a researcher at the Department of Medical Biochemistry and Biophysics, together with doctoral student Isabelle Isoz and laboratory assistant Else-Britt Lundström.

The U.S. authors Zacchary Pursell and Thomas A. Kunkel work at the National Institute of Environmental Health Sciences, NIH.

The article can be read at http://www.sciencemag.org/ and is titled "Yeast DNA polymerase epsilon participates in leading-strand synthesis" Pursell, Z.F., Isoz, I., Lundström, E.-B., Johansson, E., and Kunkel, T.A.

For more information, please contact Erik Johansson, Dept. of Medical Biochemistry and Biophysics, cell phone: +46 (0)73-620 50 61, phone: +46 (0)90-786 6638, e-mail erik.johansson@medchem.umu.se.

Pressofficer: Bertil Born; bertil.born@adm.umu.se; Mobile: +46-703 414 303

Bertil Born | alfa
Further information:
http://www.info.umu.se/fodb/Projekt.aspx?id=29
http://www.sciencemag.org/

Further reports about: DNA Epsilon Polymerase Strand enzyme

More articles from Life Sciences:

nachricht Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex

nachricht New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>